Non clinical

The non-clinical Drug Metabolism and Pharmacokinetic (DMPK) consultant provides services ranging from compound optimization and selection to First-In-Human (FIH) clinical trial application.

  • Strategic project support regarding compound optimization in drug discovery with focus on DMPK and pharmacokinetics & pharmacodynamics (PK/PD)
  • Design, calculation (WinNonlin) and reporting of non-clinical PK and toxicokinetic (TK) studies
  • Design and interpretation (PKPD) of non-clinical pharmacology studies
  • Project support of clinical trial-enabling studies with focus on PK, PK/PD, TK, drug metabolism, drug-drug interaction (DDI) and bioanalysis
  • Prediction of human PK and human efficacious doses with help of in vivo-in vitro extrapolation, allometry and physiological based-pharmacokinetics (PBPK)
  • Support regarding scientific publications, scientific advice meetings and due diligence assessments
  • Experience in small molecules, peptides, therapeutic proteins, ATMPs, oligonucleotides and radiopharmaceuticals
  • Integrated non-clinical support available together with CTC’s sister companies RegSmart Life Science AB, Toxicology Knowledge Team Sweden AB (TKT), Lablytica Life Science AB and MetaSafe AB.

We provide our customers with cost-effective advice, conduct and reporting of clinical trials.

Contact us