CTC Publications
Our Recent Scientific Publications
At CTC, we are committed to advancing medical science through high-quality clinical research. In close collaboration with our sponsors, our team regularly contributes to the scientific community by publishing results from trials conducted by CTC in peer-reviewed journals. Below you will find a selection of our recent scientific publications based on studies performed at CTC, reflecting the breadth and depth of our medical and scientific expertise.
CTC Publication List
(Sorted by most recent)
Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp: A repeatability study in people with T2DM and overweight/obesity.
Laitinen I, Litorp H, Sjöberg F, Ekström S, Haraldsson H, Pierrou S, Korenyushkin A, Kullberg J, Southekal S, Lu M, Coskun T, Milicevic Z, Johansson L. EJNMMI Res. 2025 Aug 7;15(1):105. doi: 10.1186/s13550-025-01298-4. PMID: 40775126; PMCID: PMC12331569.
Read more: https://doi.org/10.1186/s13550-025-01298-4
The Supportive Effect of Acarbose to Orlistat in Weight Management-A Randomized, Double-Blind, Multiarm Phase 2 Trial.
Holmbäck U, Grudén S, Kuusk S, Litorp H, Englund J, Söderhäll A, Alderborn G, Forslund A. Obesity (Silver Spring). 2025 Aug 6. doi: 10.1002/oby.24369. PMID: 40769876
Read more: https://doi.org/10.1002/oby.24369
NLX-112 Randomized Phase 2A Trial: Safety, Tolerability, Anti-Dyskinetic, and Anti-Parkinsonian Efficacy.
Svenningsson P, Odin P, Bergquist F, Wirdefeldt K, Nyholm D, Andréasson M, Markaki, I, Johansson A, Jergil M, Jankosky C, Varney M, Herbrecht F, Johnson S, Newman-Tancredi A. Mov Disord. 2025 Jun;40(6):1134-1142. PMID: 40091754 PMCID: PMC12160962 DOI: 10.1002/mds.30175
Read more: https://doi.org/10.1002/mds.30175
Characteristics, Motivations, and Preferences of Healthy Volunteers in Phase I Clinical Trials in Sweden.
Rein-Hedin E, Schultzberg M, Sjöberg F, Huss F.. J Empir Res Hum Res Ethics. 2025 Feb-Apr;20(1-2):59-70. doi: 10.1177/15562646241309142. PMID: 39865901; PMCID: PMC12052933.
Read more: https://doi.org/10.1177/15562646241309142
Characterization of the nicotine uptake and safety of Nordic spirit tobacco-free oral nicotine pouches: A randomized cross-over study.
Renard K, Nishihara D, Nilsson J, Larroque S, Martinez J, Giles L.Psychopharmacology (Berl). 2025 Apr;242(4):855-865. doi: 10.1007/s00213-024-06721-7. PMID: 39578274; PMCID: PMC11890228.
Read more: https://doi.org/10.1007/s00213-024-06721-7
A Comparative Analysis of the Pharmacodynamic and Pharmacokinetic Properties of 2 Controlled-Release Formulations Versus a Marketed Orlistat Product.
Grudén S, Forslund A, Litorp H, Kuusk S, Alderborn G, Söderhäll A, Holmbäck U. Clin Pharmacol Drug Dev. 2025 Apr;14(4):304-310. doi: 10.1002/cpdd.1503. PMID: 39783852.
Read more: https://doi.org/10.1002/cpdd.1503
A Prospective, Randomized, Double-Blind, Split-Face, Comparative Study to Evaluate the Efficacy and Safety of DKL23 and Juvéderm Volift for Correcting Moderate-to-Severe Nasolabial Folds
Alimohammadi M, Furman-Assaf S, Nilsson J. Aesthet Surg J. 2024 Oct 15;44(11):1218-1226. doi: 10.1093/asj/sjae133. PMID: 38874166; PMCID: PMC11474605.
Read more: https://doi.org/10.1093/asj/sjae133
Regional lung targeting with a fluticasone/salmeterol aerosol using a bolus breath hold method of the PreciseInhale® system: A first evaluation in humans.
Gerde P, Sjöberg CO, Bäckroos H, Englund J, Wangheim M, Litorp H. Eur J Pharm Sci. 2024 May 1;196:106742. doi: 10.1016/j.ejps.2024.106742. PMID: 38460609.
Read more: https://doi.org/10.1016/j.ejps.2024.106742
ACD856, a novel positive allosteric modulator of Trk receptors, single ascending doses in healthy subjects: Safety and pharmacokinetics.
Nilsson B, Bylund J, Halldin MM, Rother M, Rein-Hedin E, Önnestam K, Segerdahl M. . Eur J Clin Pharmacol. 2024 May;80(5):717-727. doi: 10.1007/s00228-024-03645-1. Epub 2024 Feb 14. PMID: 38353689; PMCID: PMC11001683.
Read more: https://link.springer.com/article/10.1007/s00228-024-03645-1
Utilizing venous occlusion plethysmography to assess vascular effects: A study with buloxibutid, an angiotensin II type 2 receptor agonist.
Rein-Hedin E, Sjöberg F, Ganslandt C, Skoog J, Zachrisson H, Bengtsson T, Dalsgaard CJ. Clin Transl Sci. 2024 Feb;17(2):e13735. doi: 10.1111/cts.13735. PMID: 38344891; PMCID: PMC10859786.
Read more: https://doi.org/10.1111/cts.13735
Safety, Tolerability, Pharmacokinetics and Quantitative Electroencephalography Assessment of ACD856, a Novel Positive Allosteric Modulator of Trk-Receptors Following Multiple Doses in Healthy Subjects.
Önnestam K, Nilsson B, Rother M, Rein-Hedin E, Bylund J, Anderer P, Kemethofer M, Halldin MM, Sandin J, Segerdahl M. J Prev Alzheimers Dis. 2023;10(4):778-789. doi: 10.14283/jpad.2023.89. PMID: 37874100.
Read more: https://doi.org/10.14283/jpad.2023.89
First-in-Human Study to Assess the Safety, Tolerability, and Pharmacokinetics of Pirepemat, a Cortical Enhancer, in Healthy Volunteers.
Rein-Hedin E, Sjöberg F, Waters S, Sonesson C, Waters N, Huss F, Tedroff J. Clin Pharmacol Drug Dev. 2021 Dec;10(12):1485-1494. doi: 10.1002/cpdd.959. Epub 2021 Jun 12. PMID: 34118179.
Read more: https://doi.org/10.1002/cpdd.959
3 Slow-release L-cysteine capsule prevents gastric mucosa exposure to carcinogenic acetaldehyde: results of a randomised single-blinded, cross-over study of Helicobacter-associated atrophic gastritis
Per M Hellström 1, Panu Hendolin 2, Pertti Kaihovaara 2 3, Leif Kronberg 4, Axel Meierjohann 4, Anders Millerhovf 5, Lea Paloheimo 2, Heidi Sundelin 4, Kari Syrjänen 2, Dominic-Luc Webb 1, Mikko Salaspuro, Scand J Gastroentero. 2017 Feb;52(2):230-237. doi: 10.1080/00365521.2016.1249403. Epub 2016 Nov 3. PMID: 27806647 DOI: 10.1080/00365521.2016.1249403
Read more: https://www.tandfonline.com/doi/full/10.1080/00365521.2016.1249403
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