The glucose clamp technique measures how well an individual metabolises glucose, or how sensitive an individual is to insulin, by quantifying insulin secretion and resistance. It does so by means of a variable infusion of glucose, so that the blood glucose concentrations are maintained or “clamped” at a pre-defined target level. Because the plasma glucose concentration is held constant, the glucose infusion rate is an index of glucose uptake and metabolism.
There are two types of glucose clamps that are commonly used: the hyperglycaemic clamp and the euglycemic clamp. The hyperglycaemic clamp measures how fast the pancreatic beta-cells respond to glucose, and the euglycemic glamp measures the tissue’s sensitivity to insulin.
The glucose clamp technique is an important test used during the development of antidiabetic medications. CTC has experience with conducting clinical trials using glucose clamping methods and can offer expert advice on the trial design when performing studies in diabetic patients.